Innate effector-memory T cell activation regulates post-thrombotic vein wall inflammation and thrombus resolution

F. Shahneh, N. Luther, M. Brähler, F. Krebs, S. Jäckel, P. Wenzel, K. Schäfer, C. Becker (Mainz, Germany)

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Venous Thrombosis
Date: 17.02.2017,
Time: 08:00 - 09:15

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Objective: This study investigated the functional role of T cells in venous thrombosis.

Methods: Deep vein thrombosis (DVT) was induced by 80% flow reduction in the inferior vena cava (IVC) of mice. T cell recruitment and inflammatory activity was followed by flow cytometry, histology and intrathrombotic gene expression in reporter strains and upon depletion of T cells over various time points after DVT.

Results: DVT recruits effector-memory T cells into the vein wall and thrombus. Recruited effector-memory T cells experience an immediate antigen-independent activation and produce IFN-gamma in situ. Effector-memory T cell-derived IFN-gamma determines neutrophil and monocyte recruitment and delays thrombus neovascularization and resolution.

Conclusion: Effector-memory T cells orchestrate the inflammatory response in venous thrombosis affecting thrombus resolution.